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Indication & Dosage |
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| Oral |
| PROPHYLAXIS OF TIAS AND STROKE, RECURRENT MI AND DVT AND EMBOLISM |
| Adult:
Aspirin 60mg+Dipyridamole 25mg t.i.d. |
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| Administration |
May be taken with or without food. (Swallow whole, do not chew/ crush.) |
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| Precautions |
Unstable angina, recent MI, subaortic stenosis, history of peptic ulcer, bronchospasm, history of aspirin- or NSAIDs-induced allergy, pregnancy, lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
GI disturbances, epigastric discomfort, rhinitis, urticaria, prolonged bleeding time, headache, dizziness, facial flushing, fainting, skin rash. |
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| Adverse Drug Reactions |
Gastric erosion, bleeding. Fatal exacerbation of airways obstruction, cerebral haemorrhage in patients with pre-existing vascular lesion. |
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| Interactions |
Effects of oral anticoagulants, methotrexate, oral hypoglycaemics potentiated. Increased risk of peptic ulceration due to alcohol, corticosteroids, analgin, NSAIDs. Aspirin levels increased by metoclopramide and reduced by phenobarbitone, urinary alkalisers. Aminophylline may reduce vasodilator effect of dipyridamole. Antacids reduce efficacy. Aspirin may antagonise effects of uricosurics, spironolactone. Preferably given after food. |
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